Expanded conditional approval is a new regulatory pathway that allows drugs to go to market more quickly, with the same rigorous safety standards.

Today we are announcing Loyal’s $45M Series B. Thank you, Wall Street Journal, for the excellent piece. This round brings Loyal’s total financing to over $125M. It is the honor of a lifetime to build Loyal with this team of scientists, veterinarians, creatives, operators, animal lovers, and investors.

The STAY study will span more than 50 sites across the country, with 1,000 senior dogs participating

Everything you need to know about study requirements and sites open for enrollment

A historic milestone in developing the first drug for healthy lifespan extension in dogs

A quick read from Dr. Ellen reflecting on her time spent talking with veterinary professionals about Loyal at a recent veterinary conference

Big implications for big dogs — and possibly humans, too

We collaborated with Banfield Pet Hospital to analyze the health records of 131,140 dogs in search of risk factors for age-related diseases

Take a trip down memory lane with me and celebrate recent wins in veterinary pharmaceutical development.

More momentum to share on our path to bringing dog longevity drugs to patients!

James is a Senior Scientist at Loyal who recently presented our findings in aging biomarkers at the Keystone Symposium 2023 conference. Here he explains how these biomarkers can help us better understand — and ultimately affect — the processes underlying aging

Dr. Brennen McKenzie often teaches continuing education courses around canine aging, and he shares resources that include foundational material on aging, clinical assessment tools, and guidelines to assist vets in creating treatment plans for senior dogs.

At Loyal we’re developing the first FDA-approved drugs explicitly intended to extend lifespan and healthspan, and being first means charting new waters.

On the path to FDA approval, we must run a clinical trial that objectively and robustly demonstrates that our drug extends dogs’ healthy lifespan, and does so safely. Because no one has developed a dog — or human — longevity drug before, we are building the path to FDA approval largely from scratch.

Last week we learned from the FDA that Loyal received protocol concurrence for our companion dog longevity study — likely the first time the FDA has given their blessing to a longevity clinical trial. Our regulatory expert Karen Greenwood weighs in on what this means for Loyal, for the field of aging, and for dogs everywhere.

Our Healthspan study results have been published in GeroScience. Let’s dive into the results.

Loyal Founder and CEO, Celine Halioua, introduces the newest addition to our Board of Directors

Does your dog have floppy ears or pointy ears, or maybe something in-between? History and biology explain why dogs come in all colors, patterns, shapes, and sizes.

We know biological samples can tell us about our dog’s health and breed ancestry, but is the saliva in your dog’s mouth enough to tell us your dog’s age and birthday? The answer is, in some ways, yes.

This month’s recap includes snapshots about research into alternative forms of treatment for aging dogs: supplements and cannabis. We also learned about the dog-human bond, both from rescue dog statistics and and a test of dog love between their humans and food.

Each participant in the X-Thousand Dogs Study will receive a report with information about their dog’s ancestry. In this post, Loyal’s Dr. John Lindo, who specializes in ancient DNA and canine evolution, explains how our understanding of the relationships between species has changed over time and what a DNA test can—and cannot—reveal about your dog’s ancestors.

Scientists have revealed insights into your dog’s super-powerful nose. They’ve also uncovered new potential solutions for skin issues, revealed information about hearing loss in aging dogs, and offered an in-depth review into how your habits and activity can affect your dog’s weight.

DNA methylation is a useful tool for assessing health and longevity—both in dogs and humans. Loyal scientists are studying aging through the lens of DNA methylation and epigenetics.

Dive into highlights from the animal health and veterinary space this month. Nutritious insect protein, the link between cancer and pollution, and happy tears are just a few of the month’s most interesting discoveries.

How are dogs like probiotics? Well, they’re cuter and furrier, but they also change our microbiome and can even reduce our risk of allergies! Let’s investigate how dogs influence our microbiome and our immune systems.

Discussing weight and how it impacts our dog’s health is important to how we think about our dog’s aging and quality of life. Here are practical tips and evidence-based advice to help your dog get to their healthiest weight.

How does movement impact longevity? Can physical activity help my dog live longer? Here’s how exercise maintains good health and slows aging.

Dogs come in an astounding range of shapes and sizes. Explore how genetic differences impact age and how Loyal is working on extending the lives and health of large dogs.

Do dogs “see” with their noses? Can my dog feel guilt? Can dogs catch monkeypox from their owners? Find out in this month’s review on canine science research.

Do you ever wonder how your dog might look, feel, or act as they advance in age? Understanding aging gives us the potential to prevent or mitigate a wide range of age-related health problems in dogs.

An average-sized dog may have 10 trillion cells in its body. If you stretched all the DNA in these cells end to end, how far would it reach?

Why I’d love to see general practitioners participate in clinical research: 5 compelling reasons from a former GP

Exercise and enrichment activities can help you protect your dog against the effects of brain aging.

One of the most important health problems in veterinary medicine today is the epidemic of obesity in our pets.

The largest study of its kind, aimed at better understanding how dogs age—and how we might help them live longer, healthier lives

Lifespan is the amount of time lived. Healthspan is the time lived with vigor and good health. Which do you think is more important?

There are now lots of devices that let us call our dogs and say “Hi!” when we aren’t at home. But are these really for our dogs, or just for us?

Sometimes our dogs seem to read us like an open book! How do they know just how we are feeling? It turns out, our faces are a clear window into our emotions for our canine friends.

Dogs are exceptionally good at understanding humans; better than any animal outside our own species. But when we talk to them, we give a lot of information besides just words.

Dogs age a lot like humans, though sadly much faster. Helping us to better understand our own aging is just one of the many gifts our canine best friends give us.

Like death and taxes, aging has long been seen as unavoidable. Science is now showing us that this may not be true.

Humans are not the only animals to yawn. Fish, birds and mammals all yawn too. And, of course, so do our favorite animals here at Loyal!

There are many theories about how aging works. Lat’s take a brief look at two: Wear & Tear and the Rate of Living.

If evolution means survival of the fittest, shouldn’t animals evolve to stay healthy and live forever? Unfortunately, the evolutionary race goes to the most fertile, not the most enduring.

This collaboration will test the effectiveness of two important pro-longevity mechanisms and support development of aging drugs for dogs and beyond.

Loyal is developing an epigenetic clock to quantify biological aging in mice, dogs, and humans, spun out of the Ideker Laboratory at UCSD. This tech will support Loyal’s development of aging drugs for dogs and beyond.